🩸 MDS is usually diagnosed when a patient is evaluated for low blood counts, although some MDS patients may show an elevated white blood cell count, platelet count, or both. The defining feature of MDS is a bone marrow aspiration and biopsy showing heavy infiltration with abnormal-looking bone marrow cells.

MDS should be considered in any patient with unexplained cytopenias (low blood counts) or clinical findings related to anaemia (insufficient amount of healthy red blood cells), infection or bleeding/bruising, morphologic dysplasia of blood or bone marrow, or unexplained bone marrow failure.

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